InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PIAS1

Summary

InnateDB Gene

IDBG-18826.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIAS1

Gene Name

protein inhibitor of activated STAT, 1

Synonyms

DDXBP1; GBP; GU/RH-II; ZMIZ3

Species

Homo sapiens

Ensembl Gene

ENSG00000033800

Encoded Proteins

IDBP-18828

protein inhibitor of activated STAT, 1

IDBP-594682

protein inhibitor of activated STAT, 1

IDBP-744557

IDBP-746079

IDBP-745931

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 12855578

PIAS1 and other PIAS proteins have been shown to function as E3-type small ubiquitin-like modifier (SUMO) ligases, and sumoylation is a modulatory mechanism for several transcription factors.

PMID 19136629

PIAS1 is a protein inhibitor of activated STAT1 and arginine methylation of PIAS1 is essential for the repressive function of PRMT1 in interferon (IFN)-dependent transcription as well as for the recruitment of PIAS1 to STAT1 target gene promoters in the late phase of the IFN response.

Entrez Gene

Summary

This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:68054179-68198603

Strand

Forward strand

Band

q23

Transcripts

ENST00000249636	ENSP00000249636
ENST00000545237	ENSP00000438574
ENST00000564009
ENST00000562190	ENSP00000457698
ENST00000567417
ENST00000564915	ENSP00000456721
ENST00000563996	ENSP00000456558
ENST00000611270

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 143 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	143 [view]
Protein-Protein	135 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019789	SUMO ligase activity
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0031625	ubiquitin protein ligase binding
GO:0050681	androgen receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007259	JAK-STAT cascade
GO:0007283	spermatogenesis
GO:0008152	metabolic process
GO:0016925	protein sumoylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033235	positive regulation of protein sumoylation
GO:0042127	regulation of cell proliferation
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051152	positive regulation of smooth muscle cell differentiation
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060334	regulation of interferon-gamma-mediated signaling pathway
GO:0065004	protein-DNA complex assembly