Version 5.4
Mus musculus Gene: Pfdn5
Summary
InnateDB Gene IDBG-188389.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pfdn5
Gene Name prefoldin 5
Synonyms 1190001O17Rik; 1700010A06Rik; D15Ertd697e; Eig1; MM-1
Species Mus musculus
Ensembl Gene ENSMUSG00000001289
Encoded Proteins
IDBP-188391
prefoldin 5
IDBP-625899
prefoldin 5
IDBP-625898
prefoldin 5
IDBP-625900
prefoldin 5
IDBP-625901
prefoldin 5
IDBP-625902
prefoldin 5
IDBP-625903
prefoldin 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123349:
This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:102326116-102331873
Strand Forward strand
Band F3
Transcripts
ENSMUST00000001335 ENSMUSP00000001335
ENSMUST00000062492 ENSMUSP00000126970
ENSMUST00000166658 ENSMUSP00000129178
ENSMUST00000168805
ENSMUST00000170627 ENSMUSP00000131245
ENSMUST00000169637 ENSMUSP00000128263
ENSMUST00000165671 ENSMUSP00000128526
ENSMUST00000165717 ENSMUSP00000132441
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0060041 retina development in camera-type eye
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0016272 prefoldin complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000123349
View Gene Order
ENSBTAG00000008935
Not yet available
Pathways
NETPATH
REACTOME
REACT_258900
Chaperonin-mediated protein folding pathway
REACT_247926
Metabolism of proteins pathway
REACT_260833
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_245534
Protein folding pathway
REACT_245663
Prefoldin mediated transfer of substrate to CCT/TriC pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_16936
Prefoldin mediated transfer of substrate to CCT/TriC pathway
REACT_16952
Protein folding pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_17015
Metabolism of proteins pathway
REACT_17029
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_223239
Prefoldin mediated transfer of substrate to CCT/TriC pathway
REACT_203284
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_219091
Chaperonin-mediated protein folding pathway
REACT_213782
Metabolism of proteins pathway
REACT_215927
Protein folding pathway
KEGG
INOH
PID NCI
p73pathway
p73 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.305461
RefSeq NM_027044
OMIM
CCDS CCDS37227
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca