InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ntn1

Summary

InnateDB Gene

IDBG-188640.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ntn1

Gene Name

netrin 1

Synonyms

AI561871; BC019633; Netrin-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020902

Encoded Proteins

IDBP-188642

netrin 1

IDBP-264036

netrin 1

IDBP-535976

netrin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22231519

Ntn1 inhibits Ccl2 and Ccl19-mediated chemotaxis in macrophages and promotes atherosclerosis by retaining macrophages in the artery wall.

InnateDB Annotation from Orthologs

Summary

PMID 22231519

[Homo sapiens] NTN1 inhibits CCL2 and CCL19-mediated chemotaxis in macrophages and promotes atherosclerosis by retaining macrophages in the artery wall. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065320:
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:68209364-68400823

Strand

Reverse strand

Band

Transcripts

ENSMUST00000021284	ENSMUSP00000021284
ENSMUST00000108674	ENSMUSP00000104314
ENSMUST00000135141	ENSMUSP00000121193

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001764	neuron migration
GO:0006915	apoptotic process
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0008284	positive regulation of cell proliferation
GO:0016337	single organismal cell-cell adhesion
GO:0030334	regulation of cell migration
GO:0030517	negative regulation of axon extension
GO:0030879	mammary gland development
GO:0033564	anterior/posterior axon guidance
GO:0040023	establishment of nucleus localization
GO:0042472	inner ear morphogenesis
GO:0045087	innate immune response (InnateDB)
GO:0045773	positive regulation of axon extension
GO:0060603	mammary gland duct morphogenesis