InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fgfrl1

Summary

InnateDB Gene

IDBG-188643.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fgfrl1

Gene Name

fibroblast growth factor receptor-like 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000008090

Encoded Proteins

IDBP-188645

fibroblast growth factor receptor-like 1

IDBP-255756

fibroblast growth factor receptor-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127418:
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:108694229-108706950

Strand

Forward strand

Band

Transcripts

ENSMUST00000013633	ENSMUSP00000013633
ENSMUST00000112560	ENSMUSP00000108179

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001571	non-tyrosine kinase fibroblast growth factor receptor activity
GO:0005007	fibroblast growth factor-activated receptor activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0017134	fibroblast growth factor binding

Biological Process

GO:0001501	skeletal system development
GO:0003179	heart valve morphogenesis
GO:0007166	cell surface receptor signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
GO:0060412	ventricular septum morphogenesis
GO:0060539	diaphragm development

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000127418

View Gene Order

ENSBTAG00000027464

Not yet available

Cross-References

SwissProt

Q91V87

TrEMBL

UniProt Splice Variant

Entrez Gene

116701

UniGene

Mm.35691

RefSeq

NM_001164259 NM_054071

OMIM

CCDS

CCDS19518 CCDS51592

HPRD

IMGT

MGI ID

MGI:2150920

MGI Symbol

Fgfrl1

EMBL

AF321300 AF321301 AF321302 AJ293947 AJ308490 BC058745

GenPept

AAH58745 AAL06295 AAL06296 AAL06297 CAC82376 CAC83768

RNA Seq Atlas

116701