InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Guca1a

Summary

InnateDB Gene

IDBG-189055.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Guca1a

Gene Name

guanylate cyclase activator 1a (retina)

Synonyms

GC-A; Gcap1; Guca1; mGCAP1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023982

Encoded Proteins

IDBP-189057

guanylate cyclase activator 1a (retina)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000048545:
This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:47394560-47400584

Strand

Reverse strand

Band

Transcripts

ENSMUST00000059348

ENSMUSP00000060027

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0008048	calcium sensitive guanylate cyclase activator activity
GO:0030249	guanylate cyclase regulator activity

Biological Process

GO:0007165	signal transduction
GO:0007601	visual perception
GO:0007602	phototransduction
GO:0030828	positive regulation of cGMP biosynthetic process
GO:0031282	regulation of guanylate cyclase activity
GO:0031284	positive regulation of guanylate cyclase activity

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005578	proteinaceous extracellular matrix
GO:0005886	plasma membrane
GO:0016020	membrane