InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ltbr

Summary

InnateDB Gene

IDBG-189788.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ltbr

Gene Name

lymphotoxin B receptor

Synonyms

AI256028; CD18; Ltar; LTbetaR; TNF-R-III; Tnfbr; TNFCR; TNFR-RP; TNFR2-RP; TNFRrp; Tnfrsf3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030339

Encoded Proteins

IDBP-189790

lymphotoxin B receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21767811

Ltbr signalling in the gut lymphoid follicles regulates Il22 production by innate lymphoid cells in response to mucosal pathogen challenge.

InnateDB Annotation from Orthologs

Summary

PMID 20226692

[Homo sapiens] LTBR signalling in intestinal epithelial cells orchestrates innate immune responses against mucosal bacterial infection.

PMID 21767811

[Homo sapiens] LTBR signalling in the gut lymphoid follicles regulates IL22 production by innate lymphoid cells in response to mucosal pathogen challenge. (Demonstrated in mouse)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111321:
This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:125306571-125313885

Strand

Reverse strand

Band

Transcripts

ENSMUST00000032489	ENSMUSP00000032489
ENSMUST00000161891
ENSMUST00000160901

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding

Biological Process

GO:0006915	apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0046330	positive regulation of JNK cascade
GO:0048535	lymph node development
GO:0071260	cellular response to mechanical stimulus
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0016021

integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000111321

View Gene Order

ENSBTAG00000015312

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04060

Cytokine-cytokine receptor interaction pathway

mmu04672

Intestinal immune network for IgA production pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04672

Intestinal immune network for IgA production pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.3122

RefSeq

NM_010736

OMIM

CCDS

CCDS20549

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas