InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gabrb3

Summary

InnateDB Gene

IDBG-190262.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gabrb3

Gene Name

gamma-aminobutyric acid (GABA) A receptor, subunit beta 3

Synonyms

A230092K12Rik; AW049585; beta3; Cp1; Gabrb-3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000033676

Encoded Proteins

IDBP-190264

gamma-aminobutyric acid (GABA) A receptor, subunit beta 3

IDBP-190266

gamma-aminobutyric acid (GABA) A receptor, subunit beta 3

IDBP-541066

gamma-aminobutyric acid (GABA) A receptor, subunit beta 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166206:
This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one of at least 13 distinct subunits of a multisubunit chloride channel that serves as the receptor for gamma-aminobutyric acid, the major inhibitory transmitter of the nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two genes encoding related subunits of the family. Mutations in this gene may be associated with the pathogenesis of Angelman syndrome, Prader-Willi syndrome, and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2010]
This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:57590518-57828802

Strand

Forward strand

Band

Transcripts

ENSMUST00000085240	ENSMUSP00000082337
ENSMUST00000039697	ENSMUSP00000038051
ENSMUST00000156375
ENSMUST00000138350	ENSMUSP00000118835
ENSMUST00000136033

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004890	GABA-A receptor activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005254	chloride channel activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007605	sensory perception of sound
GO:0034220	ion transmembrane transport
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0048666	neuron development
GO:0060119	inner ear receptor cell development
GO:0060384	innervation
GO:0071420	cellular response to histamine
GO:0090102	cochlea development
GO:1901215	negative regulation of neuron death
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0034707	chloride channel complex
GO:0045202	synapse
GO:0045211	postsynaptic membrane