Version 5.4
Mus musculus Gene: Nr1h3
Summary
InnateDB Gene IDBG-190792.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nr1h3
Gene Name nuclear receptor subfamily 1, group H, member 3
Synonyms AU018371; LXR; RLD1; Unr1
Species Mus musculus
Ensembl Gene ENSMUSG00000002108
Encoded Proteins
IDBP-190794
nuclear receptor subfamily 1, group H, member 3
IDBP-258297
nuclear receptor subfamily 1, group H, member 3
IDBP-258299
nuclear receptor subfamily 1, group H, member 3
IDBP-258301
nuclear receptor subfamily 1, group H, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21492741
Nr1h3 repressed Irf3- or Irf7-induced transactivation of the interferon-beta promoter and NDV infection further potentiated the repressive effect in dendritic cells.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:91184061-91202834
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000002177 ENSMUSP00000002177
ENSMUST00000111356 ENSMUSP00000106988
ENSMUST00000111355 ENSMUSP00000106987
ENSMUST00000111354 ENSMUSP00000106986
ENSMUST00000150654
ENSMUST00000130031
ENSMUST00000133261
ENSMUST00000136234
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0032810 sterol response element binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006633 fatty acid biosynthetic process
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010870 positive regulation of receptor biosynthetic process
GO:0010875 positive regulation of cholesterol efflux
GO:0010887 negative regulation of cholesterol storage
GO:0030522 intracellular receptor signaling pathway
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032369 negative regulation of lipid transport
GO:0032570 response to progesterone
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0042632 cholesterol homeostasis
GO:0043031 negative regulation of macrophage activation
GO:0043277 apoptotic cell clearance
GO:0043401 steroid hormone mediated signaling pathway
GO:0044255 cellular lipid metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0045861 negative regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048550 negative regulation of pinocytosis
GO:0050728 negative regulation of inflammatory response
GO:0051006 positive regulation of lipoprotein lipase activity
GO:0055088 lipid homeostasis
GO:0055092 sterol homeostasis
GO:0070328 triglyceride homeostasis
GO:0071222 cellular response to lipopolysaccharide
GO:0090188 negative regulation of pancreatic juice secretion
GO:0090341 negative regulation of secretion of lysosomal enzymes
GO:2000188 regulation of cholesterol homeostasis
GO:2000189 positive regulation of cholesterol homeostasis
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_234105
Nuclear Receptor transcription pathway pathway
REACT_233572
Gene Expression pathway
REACT_206529
Generic Transcription Pathway pathway
KEGG
mmu03320
PPAR signaling pathway pathway
mmu05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.22690
RefSeq NM_001177730 NM_013839 XM_006499166 XM_006499167 XM_006499168
OMIM
CCDS CCDS16426
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca