Version 5.4
Mus musculus Gene: Cd68
Summary
InnateDB Gene IDBG-191443.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd68
Gene Name CD68 antigen
Synonyms gp110; Lamp4; Scard1
Species Mus musculus
Ensembl Gene ENSMUSG00000018774
Encoded Proteins
IDBP-191445
CD68 antigen
IDBP-264076
CD68 antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129226:
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:69664213-69666153
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000018918 ENSMUSP00000018918
ENSMUST00000108654 ENSMUSP00000104294
ENSMUST00000154124
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0071310 cellular response to organic substance
Cellular Component
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000129226
View Gene Order
ENSBTAG00000000133
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt P31996
TrEMBL
UniProt Splice Variant
Entrez Gene 12514
UniGene Mm.15819
RefSeq NM_001291058 NM_009853 XM_006532109
OMIM
CCDS CCDS70216
HPRD
IMGT
MGI ID MGI:88342
MGI Symbol Cd68
EMBL AB009287 AF022651 AF039399 AF045554 AK002264 AK170443 AL603707 BC021637 DQ167574 X68273
GenPept AAC15685 AAC40056 AAC40151 AAH21637 ABA02181 BAA23738 BAB21975 BAE41801 CAA48334 CAI51942
RNA Seq Atlas 12514

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca