Version 5.4
Homo sapiens Gene: GSKIP
Summary
InnateDB Gene IDBG-19169.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSKIP
Gene Name GSK3B interacting protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000100744
Encoded Proteins
IDBP-376974
chromosome 14 open reading frame 129
IDBP-588094
chromosome 14 open reading frame 129
IDBP-594849
chromosome 14 open reading frame 129
IDBP-591733
chromosome 14 open reading frame 129
IDBP-585279
chromosome 14 open reading frame 129
IDBP-603599
chromosome 14 open reading frame 129
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:96363452-96387288
Strand Forward strand
Band q32.2
Transcripts
ENST00000438650 ENSP00000412315
ENST00000555181 ENSP00000450420
ENST00000555088
ENST00000553699 ENSP00000451072
ENST00000554182 ENSP00000451384
ENST00000556095 ENSP00000451188
ENST00000555757 ENSP00000451820
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000044715
View Gene Order
ENSBTAG00000019836
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.4104 Hs.728153 Hs.743233
RefSeq NM_001271904 NM_001271905 NM_001271906 NM_016472
HUGO
OMIM
CCDS CCDS32153
HPRD 16601
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca