InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Chrm4

Summary

InnateDB Gene

IDBG-191763.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chrm4

Gene Name

cholinergic receptor, muscarinic 4

Synonyms

Chrm-4; M4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040495

Encoded Proteins

IDBP-191765

cholinergic receptor, muscarinic 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180720:
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:91927249-91928688

Strand

Forward strand

Band

Transcripts

ENSMUST00000045537

ENSMUSP00000040808

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0016907	G-protein coupled acetylcholine receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007197	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
GO:0040012	regulation of locomotion

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane