InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mdk

Summary

InnateDB Gene

IDBG-191772.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mdk

Gene Name

midkine

Synonyms

Mek; MK

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027239

Encoded Proteins

IDBP-191774

midkine

IDBP-191776

midkine

IDBP-191778

midkine

IDBP-258403

midkine

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a secreted growth factor that belongs to the pleiotrophin/midkine heparin-binding protein family and functions in a variety of biological processes. The encoded cytokine promotes the growth, differentiation, survival and migration of several target cells including leucocytes involved in inflammation. This protein plays a role in the formation of scar tissue and intraperitoneal adhesions, and promotes neurite outgrowth and neuron survival. The protein encoded by this gene is associated with obesity and inhibition of insulin signaling in fat cells. A pseudogene of this gene is present on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:91929805-91932297

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028672	ENSMUSP00000028672
ENSMUST00000069423	ENSMUSP00000068413
ENSMUST00000090602	ENSMUSP00000088090
ENSMUST00000111309	ENSMUSP00000106941

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008083	growth factor activity
GO:0008201	heparin binding

Biological Process

GO:0001662	behavioral fear response
GO:0007614	short-term memory
GO:0009611	response to wounding
GO:0009725	response to hormone
GO:0016477	cell migration
GO:0021542	dentate gyrus development
GO:0021681	cerebellar granular layer development
GO:0021766	hippocampus development
GO:0021987	cerebral cortex development
GO:0030154	cell differentiation
GO:0030325	adrenal gland development
GO:0030421	defecation
GO:0042493	response to drug
GO:0043524	negative regulation of neuron apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050795	regulation of behavior
GO:0051384	response to glucocorticoid
GO:0051781	positive regulation of cell division
GO:1901215	negative regulation of neuron death