Version 5.4
Mus musculus Gene: Sf3b3
Summary
InnateDB Gene IDBG-192219.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sf3b3
Gene Name splicing factor 3b, subunit 3
Synonyms 1810061H24Rik; 5730409A01Rik; AA409318; D8Ertd633e; mKIAA0017; RSE1; SAP130
Species Mus musculus
Ensembl Gene ENSMUSG00000033732
Encoded Proteins
IDBP-192221
splicing factor 3b, subunit 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000189091:
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron\'s branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:110810492-110846803
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000042012 ENSMUSP00000045073
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 110 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 110 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003676 nucleic acid binding
GO:0005515 protein binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005689 U12-type spliceosomal complex
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000189091
View Gene Order
ENSBTAG00000010627
Not yet available
Pathways
NETPATH
REACTOME
REACT_249110
mRNA Splicing pathway
REACT_235610
mRNA Splicing - Minor Pathway pathway
REACT_233572
Gene Expression pathway
REACT_260226
mRNA Splicing - Major Pathway pathway
REACT_233950
Processing of Capped Intron-Containing Pre-mRNA pathway
KEGG
mmu03040
Spliceosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_1753
mRNA Splicing - Minor Pathway pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
REACT_205948
mRNA Splicing - Major Pathway pathway
REACT_206725
mRNA Splicing pathway
REACT_226022
Gene Expression pathway
REACT_226302
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_217207
mRNA Splicing - Minor Pathway pathway
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt Q921M3
TrEMBL B2RSV4
UniProt Splice Variant
Entrez Gene 101943
UniGene Mm.236123 Mm.399700
RefSeq NM_133953 XM_006530518
OMIM
CCDS CCDS22665
HPRD
IMGT
MGI ID MGI:1289341
MGI Symbol Sf3b3
EMBL AK085705 AK088268 AK129035 AK147914 BC011412 BC031197 BC042580 BC139015 BC139016 CH466525
GenPept AAH11412 AAH31197 AAH42580 AAI39016 AAI39017 BAC39513 BAC40248 BAC97845 BAE28225 EDL11472
RNA Seq Atlas 101943

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca