Version 5.4
Mus musculus Gene: Ndst3
Summary
InnateDB Gene IDBG-192318.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ndst3
Gene Name N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
Synonyms 4921531K01Rik; 4930511P15Rik; N-HSST 3; NDST-3
Species Mus musculus
Ensembl Gene ENSMUSG00000027977
Encoded Proteins
IDBP-192320
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
IDBP-536887
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
IDBP-533860
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
IDBP-537888
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
IDBP-541732
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
IDBP-620273
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164100:
This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. This monomeric bifunctional enzyme catalyzes the N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate and heparin, which are the initial chemical modifications required for the biosynthesis of the functional oligosaccharide sequences that define the specific ligand binding activities of heparan sulfate and heparin. [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:123526166-123690852
Strand Reverse strand
Band G1
Transcripts
ENSMUST00000029602 ENSMUSP00000029602
ENSMUST00000137404 ENSMUSP00000118796
ENSMUST00000154668 ENSMUSP00000118207
ENSMUST00000124803 ENSMUSP00000122617
ENSMUST00000132112 ENSMUSP00000120623
ENSMUST00000132896
ENSMUST00000172537 ENSMUSP00000133657
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008146 sulfotransferase activity
GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity
GO:0016787 hydrolase activity
GO:0019213 deacetylase activity
Biological Process
GO:0008152 metabolic process
GO:0015012 heparan sulfate proteoglycan biosynthetic process
GO:0030210 heparin biosynthetic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164100
View Gene Order
ENSBTAG00000007316
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00534
Glycosaminoglycan biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121248
HS-GAG biosynthesis pathway
REACT_147853
Mucopolysaccharidoses pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_267711
Defective B4GALT7 causes EDS, progeroid type pathway
REACT_267713
Defective CHST6 causes MCDC1 pathway
REACT_147719
MPS VI - Maroteaux-Lamy syndrome pathway
REACT_267645
Defective PAPSS2 causes SEMD-PA pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_147749
MPS IIID - Sanfilippo syndrome D pathway
REACT_267662
Defective SLC26A2 causes chondrodysplasias pathway
REACT_147739
MPS IX - Natowicz syndrome pathway
REACT_267674
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
REACT_267642
Defective CHST14 causes EDS, musculocontractural type pathway
REACT_121314
Heparan sulfate/heparin (HS-GAG) metabolism pathway
REACT_147798
MPS IV - Morquio syndrome B pathway
REACT_267659
Defective B3GAT3 causes JDSSDHD pathway
REACT_267708
Defective CHST3 causes SEDCJD pathway
REACT_147825
MPS IV - Morquio syndrome A pathway
REACT_267654
Defective EXT2 causes exostoses 2 pathway
REACT_267707
Diseases associated with glycosaminoglycan metabolism pathway
REACT_147734
MPS II - Hunter syndrome pathway
REACT_267635
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
REACT_121315
Glycosaminoglycan metabolism pathway
REACT_267705
Diseases of glycosylation pathway
REACT_147759
MPS VII - Sly syndrome pathway
REACT_267682
Defective CHSY1 causes TPBS pathway
REACT_111217
Metabolism pathway
REACT_147857
MPS I - Hurler syndrome pathway
REACT_147753
MPS IIIA - Sanfilippo syndrome A pathway
REACT_147860
MPS IIIC - Sanfilippo syndrome C pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
REACT_147788
MPS IIIB - Sanfilippo syndrome B pathway
KEGG
hsa00534
Glycosaminoglycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3YXE5 E9PZJ4
UniProt Splice Variant
Entrez Gene 83398
UniGene Mm.443908
RefSeq NM_031186 XM_006502370 XM_006502371 XM_006502372 XM_006502374
OMIM
CCDS CCDS17818
HPRD
IMGT
MGI ID MGI:1932544
MGI Symbol Ndst3
EMBL AC124005 AC160531 CH466532
GenPept EDL12296
RNA Seq Atlas 83398

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca