Version 5.4
Mus musculus Gene: Mdm4
Summary
InnateDB Gene IDBG-192393.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mdm4
Gene Name transformed mouse 3T3 cell double minute 4
Synonyms 4933417N07Rik; AA414968; AL023055; AU018793; AU021806; C85810; Mdmx
Species Mus musculus
Ensembl Gene ENSMUSG00000054387
Encoded Proteins
IDBP-192395
transformed mouse 3T3 cell double minute 4
IDBP-192397
transformed mouse 3T3 cell double minute 4
IDBP-788451
transformed mouse 3T3 cell double minute 4
IDBP-788455
transformed mouse 3T3 cell double minute 4
IDBP-788458
transformed mouse 3T3 cell double minute 4
IDBP-788460
transformed mouse 3T3 cell double minute 4
IDBP-788464
transformed mouse 3T3 cell double minute 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198625:
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter\'s degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:132959484-133030561
Strand Reverse strand
Band E4
Transcripts
ENSMUST00000067429 ENSMUSP00000070411
ENSMUST00000067398 ENSMUSP00000068661
ENSMUST00000186617 ENSMUSP00000140812
ENSMUST00000187244
ENSMUST00000188090 ENSMUSP00000140609
ENSMUST00000191212 ENSMUSP00000140006
ENSMUST00000185398 ENSMUSP00000140090
ENSMUST00000190312
ENSMUST00000189596
ENSMUST00000186513
ENSMUST00000187529
ENSMUST00000185418
ENSMUST00000190807 ENSMUSP00000140284
ENSMUST00000186645
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006461 protein complex assembly
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0042177 negative regulation of protein catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0045023 G0 to G1 transition
GO:0050821 protein stabilization
GO:0071157 negative regulation of cell cycle arrest
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198625
View Gene Order
ENSBTAG00000006255
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04115
p53 signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
p53regulationpathway
p53 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 17248
UniGene
RefSeq XM_006544352 NM_008575 XM_006529232 XM_006529233 XM_006529234
OMIM
CCDS CCDS15290
HPRD
IMGT
MGI ID MGI:107934
MGI Symbol Mdm4
EMBL
GenPept
RNA Seq Atlas 102641776 17248

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca