InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cldn7

Summary

InnateDB Gene

IDBG-192929.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cldn7

Gene Name

claudin 7

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018569

Encoded Proteins

IDBP-192931

claudin 7

IDBP-200000

claudin 7

IDBP-264198

claudin 7

IDBP-264200

claudin 7

IDBP-717373

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed constitutively in the mammary epithelium throughout development, and might be involved in vesicle trafficking to the basolateral membrane. It is essential for NaCl homeostasis in distal nephrons. The knockout mice lacking this gene showed severe salt wasting, chronic dehydration, and growth retardation, and died within 12 days after birth. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:69964779-69967885

Strand

Forward strand

Band

Transcripts

ENSMUST00000018713	ENSMUSP00000018713
ENSMUST00000060651	ENSMUSP00000090725
ENSMUST00000108597	ENSMUSP00000104238
ENSMUST00000108596	ENSMUSP00000104237
ENSMUST00000151515	ENSMUSP00000137627

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0016338

calcium-independent cell-cell adhesion

Cellular Component

GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016328	lateral plasma membrane