Version 5.4
Mus musculus Gene: Il20rb
Summary
InnateDB Gene IDBG-193159.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il20rb
Gene Name interleukin 20 receptor beta
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000044244
Encoded Proteins
IDBP-193161
interleukin 20 receptor beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 24677051
Astrocytes produce IL19 and express IL19 receptors (Il20ra and Il20rb) in response to bacterial pathogens. IL19 can significantly attenuate bacterially induced inflammatory astrocyte responses
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174564:
IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:100457719-100486788
Strand Reverse strand
Band E3.3
Transcripts
ENSMUST00000098458 ENSMUSP00000096057
ENSMUST00000136606
ENSMUST00000136856
ENSMUST00000125259
ENSMUST00000152756
ENSMUST00000122880
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042015 interleukin-20 binding
Biological Process
GO:0001808 negative regulation of type IV hypersensitivity
GO:0002437 inflammatory response to antigenic stimulus
GO:0002765 immune response-inhibiting signal transduction
GO:0032689 negative regulation of interferon-gamma production
GO:0032703 negative regulation of interleukin-2 production
GO:0032733 positive regulation of interleukin-10 production
GO:0032753 positive regulation of interleukin-4 production
GO:0042130 negative regulation of T cell proliferation
GO:0045087 innate immune response (InnateDB)
GO:0048873 homeostasis of number of cells within a tissue
GO:0050863 regulation of T cell activation
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000174564
View Gene Order
ENSBTAG00000008299
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001033543
OMIM
CCDS CCDS23438
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca