Version 5.4
Mus musculus Gene: Ppp2r3a
Summary
InnateDB Gene IDBG-193637.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp2r3a
Gene Name protein phosphatase 2, regulatory subunit B'', alpha
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000043154
Encoded Proteins
IDBP-193639
protein phosphatase 2, regulatory subunit B'', alpha
IDBP-193641
protein phosphatase 2, regulatory subunit B'', alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000073711:
This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]
This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B\'/PR61, and B\'\'/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B\'\' family. The B\'\' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B\'\'. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:101105084-101251795
Strand Reverse strand
Band E4
Transcripts
ENSMUST00000066773 ENSMUSP00000069688
ENSMUST00000075941 ENSMUSP00000075327
ENSMUST00000185719
ENSMUST00000188612
ENSMUST00000185887
ENSMUST00000185735
ENSMUST00000191226
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0001754 eye photoreceptor cell differentiation
GO:0007525 somatic muscle development
GO:0045732 positive regulation of protein catabolic process
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090249 regulation of cell motility involved in somitogenic axis elongation
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0000159 protein phosphatase type 2A complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000073711
View Gene Order
ENSBTAG00000023416
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03015
mRNA surveillance pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa03015
mRNA surveillance pathway pathway
INOH
INOH website
Insulin receptor signaling pathway
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.335386 Mm.478431 Mm.478589
RefSeq NM_001161362 NM_172144 XM_006511701 XM_006511703 XM_006511704
OMIM
CCDS CCDS52899 CCDS52900
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca