Version 5.4
| Homo sapiens Gene: DUSP8 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-19372.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | DUSP8 | ||||||||||||||||||
| Gene Name | dual specificity phosphatase 8 | ||||||||||||||||||
| Synonyms | C11orf81; HB5; HVH-5; HVH8 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000184545 | ||||||||||||||||||
| Encoded Proteins |
dual specificity phosphatase 8
dual specificity phosphatase 8
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 11:1554044-1571920 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p15.5 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME | |||||||||||||||||||
| KEGG |
MAPK signaling pathway pathway
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| INOH | |||||||||||||||||||
| PID NCI |
ATF-2 transcription factor network
Regulation of p38-alpha and p38-beta
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| Cross-References | |||||||||||||||||||
| SwissProt | Q13202 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 1850 | ||||||||||||||||||
| UniGene | Hs.41688 Hs.604243 | ||||||||||||||||||
| RefSeq | NM_004420 XM_005253274 XM_006725533 | ||||||||||||||||||
| HUGO | HGNC:3074 | ||||||||||||||||||
| OMIM | 602038 | ||||||||||||||||||
| CCDS | CCDS7724 | ||||||||||||||||||
| HPRD | 03617 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AP006285 BC038231 BC045110 U27193 | ||||||||||||||||||
| GenPept | AAA83151 AAH38231 AAH45110 | ||||||||||||||||||
| RNA Seq Atlas | 101927562 1850 | ||||||||||||||||||