Version 5.4
Mus musculus Gene: C3
Summary
InnateDB Gene IDBG-193788.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C3
Gene Name complement component 3
Synonyms AI255234; ASP; HSE-MSF; Plp
Species Mus musculus
Ensembl Gene ENSMUSG00000024164
Encoded Proteins
IDBP-193790
complement component 3
IDBP-713211
IDBP-712939
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 24273177
C3a and its receptor C3ar1 are critical for defense against C. psittaci in mouse lung infection.
InnateDB Annotation from Orthologs
Summary
PMID 16875735
[Homo sapiens] Central protein of the complement system; Classical, lectin and alternative pathways of complement all converge at the activation of C3 yielding a diverse set of biological responses
PMID 24315997
[Homo sapiens] T cell-expressed CTSL1 cleaves C3 into active C3a and C3b fragments mediating the intracellular and extracellular C3 activation in T cells.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125730:
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:57203970-57228136
Strand Reverse strand
Band D
Transcripts
ENSMUST00000024988 ENSMUSP00000024988
ENSMUST00000177425 ENSMUSP00000135663
ENSMUST00000177046 ENSMUSP00000135560
ENSMUST00000176457
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0031715 C5L2 anaphylatoxin chemotactic receptor binding
Biological Process
GO:0001798 positive regulation of type IIa hypersensitivity
GO:0001934 positive regulation of protein phosphorylation
GO:0001970 positive regulation of activation of membrane attack complex
GO:0006631 fatty acid metabolic process
GO:0006954 inflammatory response
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0010828 positive regulation of glucose transport
GO:0010866 regulation of triglyceride biosynthetic process
GO:0010884 positive regulation of lipid storage
GO:0010951 negative regulation of endopeptidase activity
GO:0045087 innate immune response (InnateDB)
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0050766 positive regulation of phagocytosis
GO:2000427 positive regulation of apoptotic cell clearance
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000125730
View Gene Order
ENSBTAG00000017280
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_223625
GPCR downstream signaling pathway
REACT_208792
Complement cascade pathway
REACT_198562
Regulation of Complement cascade pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_202937
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_230745
Immune System pathway
REACT_231468
GPCR ligand binding pathway
REACT_218037
Alternative complement activation pathway
REACT_235286
Peptide ligand-binding receptors pathway
REACT_250376
G alpha (i) signalling events pathway
REACT_202834
Initial triggering of complement pathway
REACT_229531
Adaptive Immune System pathway
REACT_188257
Signal Transduction pathway
REACT_213087
Activation of C3 and C5 pathway
KEGG
mmu04610
Complement and coagulation cascades pathway
mmu05322
Systemic lupus erythematosus pathway
mmu05150
Staphylococcus aureus infection pathway
mmu05140
Leishmaniasis pathway
mmu04145
Phagosome pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_7972
Activation of C3 and C5 pathway
REACT_8001
Alternative complement activation pathway
REACT_8024
Initial triggering of complement pathway
REACT_118707
Regulation of Complement cascade pathway
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_6932
Complement cascade pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
hsa05322
Systemic lupus erythematosus pathway
hsa05140
Leishmaniasis pathway
hsa05150
Staphylococcus aureus infection pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa04145
Phagosome pathway
INOH
PID NCI
erb_genomic_pathway
Validated nuclear estrogen receptor beta network
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
integrin2_pathway
Beta2 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL H3BL60
UniProt Splice Variant
Entrez Gene 12266
UniGene Mm.19131
RefSeq NM_009778 XM_006544494
OMIM
CCDS CCDS37670
HPRD
IMGT
MGI ID MGI:88227
MGI Symbol C3
EMBL CH466537 CT025692
GenPept EDL38246
RNA Seq Atlas 102642251 12266

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca