InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fanci

Summary

InnateDB Gene

IDBG-193791.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fanci

Gene Name

Fanconi anemia, complementation group I

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039187

Encoded Proteins

IDBP-193795

Fanconi anemia, complementation group I

IDBP-400531

Fanconi anemia, complementation group I

IDBP-400526

Fanconi anemia, complementation group I

IDBP-538875

Fanconi anemia, complementation group I

IDBP-534059

Fanconi anemia, complementation group I

IDBP-532859

Fanconi anemia, complementation group I

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140525:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group I. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:79391929-79450265

Strand

Forward strand

Band

Transcripts

ENSMUST00000036865	ENSMUSP00000044931
ENSMUST00000117227	ENSMUSP00000112383
ENSMUST00000118959	ENSMUSP00000114122
ENSMUST00000126456	ENSMUSP00000114513
ENSMUST00000132091	ENSMUSP00000122113
ENSMUST00000137667	ENSMUSP00000117992

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0070182	DNA polymerase binding

Biological Process

GO:0006281	DNA repair
GO:0007049	cell cycle
GO:0031398	positive regulation of protein ubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000140525

View Gene Order

ENSBTAG00000009097

Not yet available

Pathways

NETPATH

REACTOME

REACT_233397

DNA Repair pathway

REACT_232842

Fanconi Anemia pathway pathway

REACT_260435

Regulation of the Fanconi anemia pathway pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_18265

Regulation of the Fanconi anemia pathway pathway

REACT_18410

Fanconi Anemia pathway pathway

REACT_216

DNA Repair pathway

KEGG

INOH

PID NCI

fanconi_pathway

Fanconi anemia pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.349493

RefSeq

NM_145946 XM_006540738 XM_006540739

OMIM

CCDS

CCDS39991

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas