InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dusp16

Summary

InnateDB Gene

IDBG-194120.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dusp16

Gene Name

dual specificity phosphatase 16

Synonyms

3830417M17Rik; AW558566; D6Ertd213e; MKP-7; MKP7; Mkpm

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030203

Encoded Proteins

IDBP-194126

dual specificity phosphatase 16

IDBP-533292

dual specificity phosphatase 16

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24311790

Dusp16 has a dual function in the innate immune system shaping the output of cytokines and other TLR-induced gene products by macrophages, most notably IL12, and regulating the responsiveness of bone marrow progenitor cells to the growth factor GM-CSF

InnateDB Annotation from Orthologs

Summary

PMID 11489891

[Homo sapiens] DUSP16 mitogen activated phosphotase that negatively regulates MAPK activity and acts as a shuttle protein, determining the localization of MAPKs in the cytoplasm.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111266:
This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:134715473-134792625

Strand

Reverse strand

Band

Transcripts

ENSMUST00000100857	ENSMUSP00000098419
ENSMUST00000129433	ENSMUSP00000115925
ENSMUST00000148926
ENSMUST00000149776

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0043409	negative regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000111266

View Gene Order

ENSBTAG00000010763

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04010

MAPK signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04010

MAPK signaling pathway pathway

INOH

PID NCI

p38alphabetapathway

Regulation of p38-alpha and p38-beta

Cross-References

SwissProt

TrEMBL

F6UIK0

UniProt Splice Variant

Entrez Gene

70686

UniGene

Mm.3994 Mm.490020

RefSeq

NM_001048054 NM_130447 XM_006506586 XM_006506587 XM_006506588

OMIM

CCDS

CCDS39679

HPRD

IMGT

MGI ID

MGI:1917936

MGI Symbol

Dusp16

EMBL

AC122193 AC126692

GenPept

RNA Seq Atlas

70686