Version 5.4
Mus musculus Gene: Dkk2
Summary
InnateDB Gene IDBG-194538.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dkk2
Gene Name dickkopf homolog 2 (Xenopus laevis)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000028031
Encoded Proteins
IDBP-194540
dickkopf homolog 2 (Xenopus laevis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155011:
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:132085292-132180293
Strand Forward strand
Band G3
Transcripts
ENSMUST00000029665 ENSMUSP00000029665
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000155011
View Gene Order
ENSBTAG00000012969
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04310
Wnt signaling pathway pathway
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_200643
negative regulation of TCF-dependent signaling by WNT ligand antagonists pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
KEGG
hsa04310
Wnt signaling pathway pathway
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
ps1pathway
Presenilin action in Notch and Wnt signaling
Cross-References
SwissProt Q9QYZ8
TrEMBL
UniProt Splice Variant
Entrez Gene 56811
UniGene Mm.103593
RefSeq NM_020265
OMIM
CCDS CCDS17844
HPRD
IMGT
MGI ID MGI:1890663
MGI Symbol Dkk2
EMBL AC127260 AJ243963 AK028225 AK031749 BC096448 CH466532
GenPept AAH96448 BAC25824 BAC27536 CAB60110 EDL12195
RNA Seq Atlas 56811

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca