InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tet2

Summary

InnateDB Gene

IDBG-195027.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tet2

Gene Name

tet methylcytosine dioxygenase 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040943

Encoded Proteins

IDBP-195029

tet oncogene family member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26287468

Tet2 selectively mediates active repression of Il6 transcription via Nfkbiz and Hdac2 during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages.

InnateDB Annotation from Orthologs

Summary

PMID 26287468

[Homo sapiens] TET2 selectively mediates active repression of IL6 transcription via NFKBIZ and HDAC2 during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168769:
The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:133463679-133544390

Strand

Reverse strand

Band

Transcripts

ENSMUST00000098603

ENSMUSP00000096203

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	35 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008198	ferrous iron binding
GO:0008270	zinc ion binding
GO:0070579	methylcytosine dioxygenase activity

Biological Process

GO:0001822	kidney development
GO:0006211	5-methylcytosine catabolic process
GO:0006493	protein O-linked glycosylation
GO:0007049	cell cycle
GO:0009791	post-embryonic development
GO:0030097	hemopoiesis
GO:0030099	myeloid cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0055114	oxidation-reduction process
GO:0080111	DNA demethylation
GO:0080182	histone H3-K4 trimethylation

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000168769

View Gene Order

ENSBTAG00000017682

Not yet available

Pathways

NETPATH

REACTOME

REACT_205737

Epigenetic regulation of gene expression pathway

REACT_223022

TET1,2,3 and TDG demethylate DNA pathway

REACT_233572

Gene Expression pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_200682

TET1,2,3 and TDG demethylate DNA pathway

REACT_200857

Epigenetic regulation of gene expression pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q4JK59

TrEMBL

UniProt Splice Variant

Entrez Gene

214133

UniGene

Mm.347816 Mm.407133

RefSeq

NM_001040400 XM_006501286 XM_006501287

OMIM

CCDS

CCDS51071

HPRD

IMGT

MGI ID

MGI:2443298

MGI Symbol

Tet2

EMBL

AK129389 AK151359 AK152297 AK153251 AK153311 AK153460 BC031159 BC040785 DQ079067

GenPept

AAH31159 AAH40785 AAY90126 BAC98199 BAE30334 BAE31106 BAE31842 BAE31892 BAE32012

RNA Seq Atlas

214133