Version 5.4
Mus musculus Gene: Arhgdib
Summary
InnateDB Gene IDBG-195168.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgdib
Gene Name Rho, GDP dissociation inhibitor (GDI) beta
Synonyms D4; Gdid4; Ly-GDI
Species Mus musculus
Ensembl Gene ENSMUSG00000030220
Encoded Proteins
IDBP-195170
Rho, GDP dissociation inhibitor (GDI) beta
IDBP-257172
Rho, GDP dissociation inhibitor (GDI) beta
IDBP-257174
Rho, GDP dissociation inhibitor (GDI) beta
IDBP-533671
Rho, GDP dissociation inhibitor (GDI) beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the Rho guanine nucleotide dissociation inhibitor (GDI) family. This gene is expressed at high levels in hematopoietic cells. This protein is cytosolic, and dissociation of Rho from this protein is required for membrane association and activation of Rho by Guanine Nucleotide Exchange Factors (GEFs). C-terminal truncations of this gene product have been reported to promote metastasis. Multiple transcript variants and protein isoforms exist. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:136923523-136941899
Strand Reverse strand
Band G1
Transcripts
ENSMUST00000032344 ENSMUSP00000032344
ENSMUST00000111892 ENSMUSP00000107523
ENSMUST00000111891 ENSMUSP00000107522
ENSMUST00000154440 ENSMUSP00000120047
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005094 Rho GDP-dissociation inhibitor activity
GO:0005096 GTPase activator activity
Biological Process
GO:0043547 positive regulation of GTPase activity
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000111348
View Gene Order
ENSBTAG00000006039
Not yet available
Pathways
NETPATH
REACTOME
REACT_206918
Signaling by Rho GTPases pathway
REACT_210090
Rho GTPase cycle pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04722
Neurotrophin signaling pathway pathway
mmu04962
Vasopressin-regulated water reabsorption pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
REACT_211150
Rho GTPase cycle pathway
REACT_214353
Signal Transduction pathway
REACT_209608
Signaling by Rho GTPases pathway
KEGG
hsa04722
Neurotrophin signaling pathway pathway
hsa04962
Vasopressin-regulated water reabsorption pathway
INOH
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.2241 Mm.486330
RefSeq NM_007486 XM_006505403 XM_006505404 XM_006505405 XM_006505406 XM_006505407
OMIM
CCDS CCDS20661
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca