Version 5.4
Mus musculus Gene: Pde6h
Summary
InnateDB Gene IDBG-195204.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pde6h
Gene Name phosphodiesterase 6H, cGMP-specific, cone, gamma
Synonyms A930033D18Rik; PDEgamma
Species Mus musculus
Ensembl Gene ENSMUSG00000064330
Encoded Proteins
IDBP-540041
phosphodiesterase 6H, cGMP-specific, cone, gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139053:
This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A). [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:136954523-136968865
Strand Forward strand
Band G1
Transcripts
ENSMUST00000057650
ENSMUST00000137768 ENSMUSP00000119246
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0030553 cGMP binding
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0007601 visual perception
GO:0008152 metabolic process
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway
GO:0050896 response to stimulus
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000139053
View Gene Order
ENSBTAG00000013635
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00230
Purine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
cone_pathway
Visual signal transduction: Cones
Cross-References
SwissProt P61249
TrEMBL Q8R4Y2
UniProt Splice Variant
Entrez Gene 78600
UniGene Mm.290622
RefSeq NM_023898 XM_006506773 XM_006506774
OMIM
CCDS CCDS39686
HPRD
IMGT
MGI ID MGI:1925850
MGI Symbol Pde6h
EMBL AC125341 AF190929 AF303954 AK020922 BC115671 BC115672 CH466572
GenPept AAG17170 AAI15672 AAI15673 AAM18356 BAB32255 EDL10581
RNA Seq Atlas 78600

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca