Version 5.4
Homo sapiens Gene: TM4SF5
Summary
InnateDB Gene IDBG-19571.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TM4SF5
Gene Name transmembrane 4 L six family member 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000142484
Encoded Proteins
IDBP-19575
transmembrane 4 L six family member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:4771884-4783213
Strand Forward strand
Band p13.2
Transcripts
ENST00000270560 ENSP00000270560
ENST00000576530
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018919
View Gene Order
ENSBTAG00000003733
Not yet available
Cross-References
SwissProt O14894
TrEMBL
UniProt Splice Variant
Entrez Gene 9032
UniGene
RefSeq NM_003963
HUGO HGNC:11857
OMIM 604657
CCDS CCDS11054
HPRD
IMGT
EMBL AF027204 BC069519 BC093688 BC117163 CR456925
GenPept AAB82947 AAH69519 AAH93688 AAI17164 CAG33206
RNA Seq Atlas 9032

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca