InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Acy1

Summary

InnateDB Gene

IDBG-196000.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acy1

Gene Name

aminoacylase 1

Synonyms

1110014J22Rik; Acy-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023262

Encoded Proteins

IDBP-196002

aminoacylase 1

IDBP-790322

aminoacylase 1

IDBP-790323

aminoacylase 1

IDBP-790324

aminoacylase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000243989:
This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:106432981-106438319

Strand

Reverse strand

Band

Transcripts

ENSMUST00000024031	ENSMUSP00000024031
ENSMUST00000189097
ENSMUST00000190851
ENSMUST00000187324
ENSMUST00000190803	ENSMUSP00000139931
ENSMUST00000190972	ENSMUSP00000139953
ENSMUST00000190900	ENSMUSP00000140582

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004046	aminoacylase activity
GO:0008237	metallopeptidase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0006520	cellular amino acid metabolic process
GO:0008152	metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000243989

View Gene Order

ENSBTAG00000032304

Not yet available

Pathways

NETPATH

REACTOME

REACT_237136

Aflatoxin activation and detoxification pathway

REACT_188937

Metabolism pathway

REACT_232343

Biological oxidations pathway

KEGG

mmu00330

Arginine and proline metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_228214

Aflatoxin activation and detoxification pathway

REACT_111217

Metabolism pathway

REACT_13433

Biological oxidations pathway

KEGG

hsa00330

Arginine and proline metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

Q99JW2

TrEMBL

UniProt Splice Variant

Entrez Gene

109652

UniGene

Mm.7165

RefSeq

NM_001276442 NM_025371

OMIM

CCDS

CCDS23477

HPRD

IMGT

MGI ID

MGI:87913

MGI Symbol

Acy1

EMBL

AK002423 AK003703 BC005631

GenPept

AAH05631 BAB22090 BAB22948

RNA Seq Atlas

109652