InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cpeb1

Summary

InnateDB Gene

IDBG-196102.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cpeb1

Gene Name

cytoplasmic polyadenylation element binding protein 1

Synonyms

AU024112; Cpeb; mCPEB

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025586

Encoded Proteins

IDBP-196106

cytoplasmic polyadenylation element binding protein 1

IDBP-542233

cytoplasmic polyadenylation element binding protein 1

IDBP-722438

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000214575:
This gene encodes a member of the cytoplasmic polyadenylation element (CPE) binding protein family. This highly conserved protein binds to a specific RNA sequence called the CPE found in the 3' UTR of some mRNAs. Similar proteins in Xenopus and mouse function to induce cytoplasmic polyadenylation of dormant mRNAs with short polyA tails, resulting in their translation. Members of this protein family regulate translation of cyclin B1 during embryonic cell divisions. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:81347026-81455465

Strand

Reverse strand

Band

Transcripts

ENSMUST00000098331	ENSMUSP00000095936
ENSMUST00000130310	ENSMUSP00000120139
ENSMUST00000152319
ENSMUST00000136689
ENSMUST00000135177
ENSMUST00000153419
ENSMUST00000151661
ENSMUST00000124937
ENSMUST00000178892	ENSMUSP00000137079

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000900	translation repressor activity, nucleic acid binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0035925	mRNA 3'-UTR AU-rich region binding
GO:0046872	metal ion binding

Biological Process

GO:0006397	mRNA processing
GO:0006417	regulation of translation
GO:0007130	synaptonemal complex assembly
GO:0032869	cellular response to insulin stimulus
GO:0048168	regulation of neuronal synaptic plasticity
GO:0071230	cellular response to amino acid stimulus
GO:0071456	cellular response to hypoxia
GO:2000766	negative regulation of cytoplasmic translation

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane
GO:0072687	meiotic spindle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000214575

View Gene Order

ENSBTAG00000000623

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04320

Dorso-ventral axis formation pathway

mmu04914

Progesterone-mediated oocyte maturation pathway

mmu04114

Oocyte meiosis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04320

Dorso-ventral axis formation pathway

hsa04914

Progesterone-mediated oocyte maturation pathway

hsa04114

Oocyte meiosis pathway

INOH

PID NCI

aurora_a_pathway

Aurora A signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.273122 Mm.410473

RefSeq

NM_001252525 NM_001252526 NM_007755

OMIM

CCDS

CCDS40007 CCDS57557

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas