Mus musculus Gene: Oas2 | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Gene | IDBG-196257.6 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | Oas2 | ||||||||||||||||
Gene Name | 2'-5' oligoadenylate synthetase 2 | ||||||||||||||||
Synonyms | |||||||||||||||||
Species | Mus musculus | ||||||||||||||||
Ensembl Gene | ENSMUSG00000032690 | ||||||||||||||||
Encoded Proteins |
2'-5' oligoadenylate synthetase 2
2'-5' oligoadenylate synthetase 2
2'-5' oligoadenylate synthetase 2
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Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
InnateDB Annotation | |||||||||||||||||
Summary |
Oas2 is a pathogen recognition receptor for the viral pathogen-associated molecular pattern, double-stranded RNA. Upon recognition of dsRNA, the Oas2 activates Rnasel to cleave ssRNA. The Oas/Rnasel pathway triggers the RIG-I pathway and induce Ifnb production.
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InnateDB Annotation from Orthologs | |||||||||||||||||
Summary |
[Homo sapiens] OAS2 is a pathogen recognition receptor for the viral pathogen-associated molecular pattern, double-stranded RNA. Upon recognition of dsRNA, the OAS2 activates RNASEL to cleave ssRNA. The OAS/RNASEL pathway triggers the RIG-I pathway and induce IFNB production.
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Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111335:
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2\'-specific nucleotidyl transfer reactions to synthesize 2\',5\'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome 5:120730333-120749853 | ||||||||||||||||
Strand | Reverse strand | ||||||||||||||||
Band | F | ||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||
NETPATH | |||||||||||||||||
REACTOME |
Cytokine Signaling in Immune system pathway
Immune System pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
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KEGG |
Hepatitis C pathway
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INOH | |||||||||||||||||
PID NCI | |||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||
NETPATH | |||||||||||||||||
REACTOME |
Interferon alpha/beta signaling pathway
Interferon gamma signaling pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Immune System pathway
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KEGG |
Hepatitis C pathway
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INOH | |||||||||||||||||
PID NCI | |||||||||||||||||
Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | |||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | |||||||||||||||||
UniGene | Mm.260926 | ||||||||||||||||
RefSeq | NM_145227 XM_006530324 XM_006530325 XM_006530326 | ||||||||||||||||
OMIM | |||||||||||||||||
CCDS | CCDS19625 | ||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
MGI ID | |||||||||||||||||
MGI Symbol | |||||||||||||||||
EMBL | |||||||||||||||||
GenPept | |||||||||||||||||
RNA Seq Atlas | |||||||||||||||||