Version 5.4
Mus musculus Gene: Prim1
Summary
InnateDB Gene IDBG-196330.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prim1
Gene Name DNA primase, p49 subunit
Synonyms AI324982
Species Mus musculus
Ensembl Gene ENSMUSG00000025395
Encoded Proteins
IDBP-196332
DNA primase, p49 subunit
IDBP-712812
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198056:
The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the small, 49 kDa primase subunit. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:128015168-128030037
Strand Forward strand
Band D3
Transcripts
ENSMUST00000026461 ENSMUSP00000026461
ENSMUST00000133285
ENSMUST00000135580
ENSMUST00000138330
ENSMUST00000178041 ENSMUSP00000136556
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003896 DNA primase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006269 DNA replication, synthesis of RNA primer
Cellular Component
GO:0016020 membrane
GO:1990077 primosome complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198056
View Gene Order
ENSBTAG00000044000
Not yet available
Pathways
NETPATH
REACTOME
REACT_262992
Processive synthesis on the lagging strand pathway
REACT_251075
Removal of the Flap Intermediate pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_233453
Chromosome Maintenance pathway
REACT_258062
Synthesis of DNA pathway
REACT_241296
DNA strand elongation pathway
REACT_224446
Telomere C-strand synthesis initiation pathway
REACT_208887
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
REACT_232628
DNA Replication pathway
REACT_252672
Telomere Maintenance pathway
REACT_188804
Cell Cycle pathway
REACT_254983
Activation of the pre-replicative complex pathway
REACT_259967
Leading Strand Synthesis pathway
REACT_220175
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_245528
M/G1 Transition pathway
REACT_253002
G1/S Transition pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_252545
Extension of Telomeres pathway
REACT_238214
DNA replication initiation pathway
REACT_245471
Polymerase switching pathway
REACT_206830
E2F mediated regulation of DNA replication pathway
REACT_245263
Lagging Strand Synthesis pathway
REACT_235483
DNA Replication Pre-Initiation pathway
REACT_225604
Polymerase switching on the C-strand of the telomere pathway
REACT_253623
S Phase pathway
KEGG
mmu00240
Pyrimidine metabolism pathway
mmu03030
DNA replication pathway
mmu00230
Purine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_7987
Polymerase switching on the C-strand of the telomere pathway
REACT_7993
Telomere C-strand synthesis initiation pathway
REACT_7961
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_2244
DNA replication initiation pathway
REACT_70
Removal of the Flap Intermediate pathway
REACT_1385
Processive synthesis on the lagging strand pathway
REACT_1792
Polymerase switching pathway
REACT_1838
Leading Strand Synthesis pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_329
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
REACT_471
E2F mediated regulation of DNA replication pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_22172
Chromosome Maintenance pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_7970
Telomere Maintenance pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_932
DNA strand elongation pathway
REACT_8030
Extension of Telomeres pathway
REACT_312
Lagging Strand Synthesis pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa03030
DNA replication pathway
hsa00230
Purine metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL J3QN19
UniProt Splice Variant
Entrez Gene 19075
UniGene Mm.2903
RefSeq NM_008921
OMIM
CCDS CCDS36086
HPRD
IMGT
MGI ID MGI:97757
MGI Symbol Prim1
EMBL AC131120
GenPept
RNA Seq Atlas 19075

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca