InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp5b

Summary

InnateDB Gene

IDBG-196497.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp5b

Gene Name

ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025393

Encoded Proteins

IDBP-196499

ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110955:
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:128083273-128090391

Strand

Forward strand

Band

Transcripts

ENSMUST00000026459	ENSMUSP00000026459
ENSMUST00000127439
ENSMUST00000139295
ENSMUST00000126040
ENSMUST00000124993
ENSMUST00000144918
ENSMUST00000123803
ENSMUST00000126751
ENSMUST00000125992

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	78 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042288	MHC class I protein binding
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0001525	angiogenesis
GO:0001649	osteoblast differentiation
GO:0006200	ATP catabolic process
GO:0006629	lipid metabolic process
GO:0006754	ATP biosynthetic process
GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0015986	ATP synthesis coupled proton transport
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0046034	ATP metabolic process
GO:0051453	regulation of intracellular pH

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005753	mitochondrial proton-transporting ATP synthase complex
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0031966	mitochondrial membrane
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain
GO:0042645	mitochondrial nucleoid
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)
GO:0070062	extracellular vesicular exosome