Version 5.4
Mus musculus Gene: Homer2
Summary
InnateDB Gene IDBG-196503.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Homer2
Gene Name homer homolog 2 (Drosophila)
Synonyms 9330120H11Rik; AW539445; CPD; Vesl-2
Species Mus musculus
Ensembl Gene ENSMUSG00000025813
Encoded Proteins
IDBP-196494
homer homolog 2 (Drosophila)
IDBP-196505
homer homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103942:
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:81600481-81706925
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000098326 ENSMUSP00000095931
ENSMUST00000026922 ENSMUSP00000026922
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0030160 GKAP/Homer scaffold activity
GO:0035254 glutamate receptor binding
GO:0035256 G-protein coupled glutamate receptor binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0007216 G-protein coupled glutamate receptor signaling pathway
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0048148 behavioral response to cocaine
GO:0048875 chemical homeostasis within a tissue
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0045177 apical part of cell
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000103942
View Gene Order
ENSBTAG00000017715
Not yet available
Cross-References
SwissProt Q9QWW1
TrEMBL E9Q4F9 Q8CFI9 Q9CTG4
UniProt Splice Variant
Entrez Gene 26557
UniGene Mm.228 Mm.407062
RefSeq NM_001164086 NM_001164087 NM_011983 XM_006540909
OMIM
CCDS CCDS40009 CCDS52284
HPRD
IMGT
MGI ID MGI:1347354
MGI Symbol Homer2
EMBL AB017136 AC130538 AC140366 AF093259 AF093260 AJ012076 AK003632 BC038314
GenPept AAC71023 AAC71024 AAH38314 BAA37088 BAB22900 CAA09909
RNA Seq Atlas 26557

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca