Version 5.4
Homo sapiens Gene: TAS2R50
Summary
InnateDB Gene IDBG-19651.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAS2R50
Gene Name taste receptor, type 2, member 50
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000212126
Encoded Proteins
IDBP-476374
taste receptor, type 2, member 50
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). See also TAS2R10 (MIM 604791).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:10985913-10986912
Strand Reverse strand
Band p13.2
Transcripts
ENST00000506868 ENSP00000424040
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0033038 bitter taste receptor activity
Biological Process
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007186 G-protein coupled receptor signaling pathway
GO:0050909 sensory perception of taste
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_18319
Class C/3 (Metabotropic glutamate/pheromone receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04742
Taste transduction pathway
INOH
PID NCI
Cross-References
SwissProt P59544
TrEMBL Q50KE2 Q50KE4
UniProt Splice Variant
Entrez Gene 259296
UniGene Hs.688194
RefSeq NM_176890
HUGO HGNC:18882
OMIM 609627
CCDS CCDS8638
HPRD 18158
IMGT
EMBL AB199231 AB199233 AC018630 AF494235 AY114088 AY724937 BC112100
GenPept AAI12101 AAM19326 AAM63538 AAU21139 BAD98104 BAD98106
RNA Seq Atlas 259296

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca