Version 5.4
Mus musculus Gene: Xaf1
Summary
InnateDB Gene IDBG-196515.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Xaf1
Gene Name XIAP associated factor 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000040483
Encoded Proteins
IDBP-196523
XIAP associated factor 1
IDBP-534620
XIAP associated factor 1
IDBP-533311
XIAP associated factor 1
IDBP-537403
XIAP associated factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132530:
This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:72301629-72313733
Strand Forward strand
Band B4
Transcripts
ENSMUST00000094041 ENSMUSP00000091583
ENSMUST00000151440 ENSMUSP00000121483
ENSMUST00000140842 ENSMUSP00000121472
ENSMUST00000146233 ENSMUSP00000123011
ENSMUST00000142921
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0006915 apoptotic process
GO:0031333 negative regulation of protein complex assembly
GO:0035456 response to interferon-beta
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000132530
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25162
Interferon alpha/beta signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.291131
RefSeq NM_001037713 NM_001291153 XM_006533569 XM_006533572
OMIM
CCDS CCDS24984 CCDS70236
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca