InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Oas1b

Summary

InnateDB Gene

IDBG-196543.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Oas1b

Gene Name

2'-5' oligoadenylate synthetase 1B

Synonyms

Flv; L1; Mmu-L1; Oas1; Oias-2; Oias2; Wnv

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029605

Encoded Proteins

IDBP-196545

2'-5' oligoadenylate synthetase 1B

IDBP-789695

2'-5' oligoadenylate synthetase 1B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21190483

Oas1b is a pathogen recognition receptor for the viral pathogen-associated molecular pattern, double-stranded RNA. Upon recognition of dsRNA, the Oas1b activates Rnasel to cleave ssRNA. The Oas/Rnasel pathway triggers the RIG-I pathway and induce Ifnb production.

Entrez Gene

Summary

This gene is a member of the 2'-5' oligoA synthetase family, which are clustered on chromosome 5. The encoded protein functions in the interferon-regulated OAS/RNase L system, which mediates RNA decay as part of the innate antiviral immunity pathway. The protein binds double-stranded RNA and oligomerizes ATP, which activate the single-stranded RNA cleavage enzyme RNase L. This protein mediates resistance to flaviviruses such as West Nile virus. The majority of wild mouse strains produce a functional protein and are resistant to flavivirus infection, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a premature stop codon that inactivates this gene product. [provided by RefSeq, Jul 2008]
This gene is a member of the 2\'-5\' oligoA synthetase family, which are clustered on chromosome 5. The encoded protein functions in the interferon-regulated OAS/RNase L system, which mediates RNA decay as part of the innate antiviral immunity pathway. The protein binds double-stranded RNA and oligomerizes ATP, which activate the single-stranded RNA cleavage enzyme RNase L. This protein mediates resistance to flaviviruses such as West Nile virus. The majority of wild mouse strains produce a functional protein and are resistant to flavivirus infection, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a premature stop codon that inactivates this gene product. [provided by RefSeq, Jul 2008]

Gene Information

Type

polymorphic_pseudogene

Genomic Location

Chromosome 5:120812635-120824163

Strand

Forward strand

Band

Transcripts

ENSMUST00000086377	ENSMUSP00000083564
ENSMUST00000182725
ENSMUST00000183291	ENSMUSP00000138088

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0005524	ATP binding
GO:0016740	transferase activity

Biological Process

GO:0006955	immune response
GO:0008152	metabolic process
GO:0009615	response to virus
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus

Cellular Component

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

KEGG

mmu05160

Hepatitis C pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.233471

RefSeq

NM_001083925

OMIM

CCDS

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas