Version 5.4
Mus musculus Gene: Oas1g
Summary
InnateDB Gene IDBG-196639.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Oas1g
Gene Name 2'-5' oligoadenylate synthetase 1G
Synonyms AI449562; L2; Mmu-L; Mmu-L2; Oas1a; Oias-1; Oias1
Species Mus musculus
Ensembl Gene ENSMUSG00000066861
Encoded Proteins
IDBP-196641
2'-5' oligoadenylate synthetase 1G
IDBP-538881
2'-5' oligoadenylate synthetase 1G
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21190483
Oas1g is a pathogen recognition receptor for the viral pathogen-associated molecular pattern, double-stranded RNA. Upon recognition of dsRNA, the Oas1g activates Rnasel to cleave ssRNA. The Oas/Rnasel pathway triggers the RIG-I pathway and induce Ifnb production.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 5:120876142-120887613
Strand Reverse strand
Band F
Transcripts
ENSMUST00000086368 ENSMUSP00000083555
ENSMUST00000162096 ENSMUSP00000124597
ENSMUST00000161809
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0016779 nucleotidyltransferase activity
Biological Process
GO:0006955 immune response
GO:0008152 metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0051607 defense response to virus
Cellular Component
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
mmu05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q8K469
UniProt Splice Variant
Entrez Gene 23960
UniGene Mm.389688
RefSeq NM_011852
OMIM
CCDS CCDS39245
HPRD
IMGT
MGI ID MGI:97429
MGI Symbol Oas1g
EMBL AC015535 AF480417 CH466529
GenPept AAM64148 EDL19744
RNA Seq Atlas 23960

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca