Version 5.4
| Mus musculus Gene: Ptpn11 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-196834.6 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Symbol | Ptpn11 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Name | protein tyrosine phosphatase, non-receptor type 11 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Synonyms | 2700084A17Rik; AW536184; PTP1D; PTP2C; SAP-2; SH-PTP2; SH-PTP3; SHP-2; Shp2; Syp | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000043733 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
protein tyrosine phosphatase, non-receptor type 11
protein tyrosine phosphatase, non-receptor type 11
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| Protein Structure | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
Ptpn11 phosphatase function positively regulates Clec7a- and Itgam-stimulated reactive oxygen species production in macrophages by dephosphorylating and thus mitigating the inhibitory function of Sirpa and by promoting Mapk1/Mapk3 activation.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] PTPN11 is a STAT5A phosphatase that specifically interacts with STAT5A in vivo in a tyrosine phosphorylation-dependent manner, leading to the down-regulation of active STAT5A.
[Homo sapiens] PTPN11 (SHP-2) phosphotyrosine phosphatase interacts with JAK tyrosine kinases to induce cytokine signal transduction.
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| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179295:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 5:121130533-121191397 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Band | F | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.
They are also associated with 103 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| REACTOME |
PD-1 signaling pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Nuclear signaling by ERBB4 pathway
Mus musculus biological processes pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
PI3K/AKT activation pathway
Disease pathway
SHC-related events pathway
RAF/MAP kinase cascade pathway
Hemostasis pathway
Prolactin receptor signaling pathway
Signaling by GPCR pathway
Signaling by Leptin pathway
Signaling by Insulin receptor pathway
Interleukin-2 signaling pathway
Netrin-1 signaling pathway
MyD88 cascade initiated on plasma membrane pathway
Signaling by VEGF pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SHC1 events in ERBB2 signaling pathway
Cytokine Signaling in Immune system pathway
VEGFR2 mediated cell proliferation pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
PIP3 activates AKT signaling pathway
Cell surface interactions at the vascular wall pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
SHC-mediated signalling pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Negative regulation of FGFR signaling pathway
Spry regulation of FGF signaling pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
ERK activation pathway
ERK1 activation pathway
SHC1 events in ERBB4 signaling pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
Signalling to RAS pathway
SHC1 events in EGFR signaling pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Signaling by EGFR pathway
Frs2-mediated activation pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Costimulation by the CD28 family pathway
Interferon Signaling pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
PI3K Cascade pathway
VEGFA-VEGFR2 Pathway pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Toll-Like Receptors Cascades pathway
Signalling to ERKs pathway
Signaling by Interleukins pathway
Interleukin-6 signaling pathway
PI3K/AKT Signaling in Cancer pathway
MyD88 dependent cascade initiated on endosome pathway
CTLA4 inhibitory signaling pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
FRS2-mediated cascade pathway
Developmental Biology pathway
SOS-mediated signalling pathway
GAB1 signalosome pathway
Activated TLR4 signalling pathway
IRS-related events pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-mediated signalling pathway
ERK2 activation pathway
ARMS-mediated activation pathway
MyD88-independent cascade pathway
Interleukin-3, 5 and GM-CSF signaling pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
GRB2 events in ERBB2 signaling pathway
Signaling by Leptin pathway
Prolonged ERK activation events pathway
Tie2 Signaling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Regulation of IFNA signaling pathway
Interferon alpha/beta signaling pathway
Signaling by FGFR pathway
GRB2 events in EGFR signaling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Netrin mediated repulsion signals pathway
FCERI mediated MAPK activation pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
SHC-related events triggered by IGF1R pathway
Signaling by EGFR in Cancer pathway
NCAM signaling for neurite out-growth pathway
Signalling to p38 via RIT and RIN pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
DAP12 interactions pathway
DAP12 signaling pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
Renal cell carcinoma pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Leukocyte transendothelial migration pathway
Adipocytokine signaling pathway pathway
Chronic myeloid leukemia pathway
Neurotrophin signaling pathway pathway
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| INOH |
JAK STAT pathway and regulation pathway
Growth hormone signaling pathway
HGF signaling pathway pathway
PDGF signaling pathway pathway
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| PID NCI | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| NETPATH |
Alpha6Beta4Integrin pathway
EGFR1 pathway
KitReceptor pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL1 pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL5 pathway
IL6 pathway
IL9 pathway
Leptin pathway
TSLP pathway
Prolactin pathway
IL11 pathway
Oncostatin_M pathway
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| REACTOME |
PIP3 activates AKT signaling pathway
ERK1 activation pathway
ERK2 activation pathway
ERK activation pathway
DAP12 signaling pathway
DAP12 interactions pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Regulation of IFNA signaling pathway
Interferon alpha/beta signaling pathway
Regulation of IFNG signaling pathway
Interferon gamma signaling pathway
Interleukin-6 signaling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Interleukin-2 signaling pathway
Prolactin receptor signaling pathway
CTLA4 inhibitory signaling pathway
PD-1 signaling pathway
Costimulation by the CD28 family pathway
Platelet sensitization by LDL pathway
Platelet homeostasis pathway
Tie2 Signaling pathway
PECAM1 interactions pathway
Cell surface interactions at the vascular wall pathway
PI3K/AKT activation pathway
Frs2-mediated activation pathway
ARMS-mediated activation pathway
Signalling to p38 via RIT and RIN pathway
Signalling to RAS pathway
SOS-mediated signalling pathway
GAB1 signalosome pathway
SHC1 events in EGFR signaling pathway
GRB2 events in EGFR signaling pathway
Signaling by EGFR pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SHC1 events in ERBB4 signaling pathway
Nuclear signaling by ERBB4 pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
PI3K Cascade pathway
SHC-mediated signalling pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
SHC-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
PI3K events in ERBB2 signaling pathway
GRB2 events in ERBB2 signaling pathway
SHC1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Spry regulation of FGF signaling pathway
Negative regulation of FGFR signaling pathway
PI-3K cascade pathway
FRS2-mediated cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signal regulatory protein (SIRP) family interactions pathway
Netrin mediated repulsion signals pathway
Netrin-1 signaling pathway
NCAM signaling for neurite out-growth pathway
Signaling by FGFR in disease pathway
SHC-related events pathway
Developmental Biology pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Cell-Cell communication pathway
Signaling by VEGF pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Axon guidance pathway
RAF/MAP kinase cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Interferon Signaling pathway
MAP kinase activation in TLR cascade pathway
IRS-mediated signalling pathway
Adaptive Immune System pathway
Immune System pathway
VEGFR2 mediated cell proliferation pathway
Insulin receptor signalling cascade pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events pathway
IGF1R signaling cascade pathway
Prolonged ERK activation events pathway
Activated TLR4 signalling pathway
PI3K/AKT Signaling in Cancer pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
Signaling by Leptin pathway
FCERI mediated MAPK activation pathway
Hemostasis pathway
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| KEGG |
Epithelial cell signaling in Helicobacter pylori infection pathway
Renal cell carcinoma pathway
Leukocyte transendothelial migration pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Chronic myeloid leukemia pathway
Adipocytokine signaling pathway pathway
Neurotrophin signaling pathway pathway
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| INOH |
JAK STAT pathway and regulation pathway
Growth hormone signaling pathway
HGF signaling pathway pathway
PDGF signaling pathway pathway
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| PID NCI |
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
IL2-mediated signaling events
TCR signaling in naïve CD4+ T cells
Integrins in angiogenesis
IGF1 pathway
EPO signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
FGF signaling pathway
Angiopoietin receptor Tie2-mediated signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
ErbB2/ErbB3 signaling events
Signaling events mediated by VEGFR1 and VEGFR2
IL3-mediated signaling events
Signaling events regulated by Ret tyrosine kinase
SHP2 signaling
IL2 signaling events mediated by STAT5
GMCSF-mediated signaling events
Fc-epsilon receptor I signaling in mast cells
VEGFR1 specific signals
IL2 signaling events mediated by PI3K
PDGFR-beta signaling pathway
IL6-mediated signaling events
Insulin Pathway
N-cadherin signaling events
IFN-gamma pathway
IL5-mediated signaling events
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| Cross-References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniGene | Mm.403894 Mm.414198 Mm.437241 Mm.444563 Mm.8681 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RefSeq | NM_001109992 NM_011202 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CCDS | CCDS39247 CCDS51637 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||