InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grem1

Summary

InnateDB Gene

IDBG-197200.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grem1

Gene Name

gremlin 1

Synonyms

Cktsf1b1; Drm; Grem; ld

Species

Mus musculus

Ensembl Gene

ENSMUSG00000074934

Encoded Proteins

IDBP-197202

gremlin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166923:
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:113746164-113758646

Strand

Reverse strand

Band

Transcripts

ENSMUST00000099575

ENSMUSP00000097170

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0030297	transmembrane receptor protein tyrosine kinase activator activity
GO:0043184	vascular endothelial growth factor receptor 2 binding
GO:0043395	heparan sulfate proteoglycan binding
GO:0048018	receptor agonist activity

Biological Process

GO:0000902	cell morphogenesis
GO:0001525	angiogenesis
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0002092	positive regulation of receptor internalization
GO:0002689	negative regulation of leukocyte chemotaxis
GO:0003257	positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0009954	proximal/distal pattern formation
GO:0010717	regulation of epithelial to mesenchymal transition
GO:0030199	collagen fibril organization
GO:0030308	negative regulation of cell growth
GO:0030326	embryonic limb morphogenesis
GO:0030502	negative regulation of bone mineralization
GO:0030514	negative regulation of BMP signaling pathway
GO:0033689	negative regulation of osteoblast proliferation
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0043542	endothelial cell migration
GO:0045766	positive regulation of angiogenesis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046851	negative regulation of bone remodeling
GO:0048263	determination of dorsal identity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051893	regulation of focal adhesion assembly
GO:0051973	positive regulation of telomerase activity
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060676	ureteric bud formation
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0090027	negative regulation of monocyte chemotaxis
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis
GO:0090291	negative regulation of osteoclast proliferation
GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation
GO:1900155	negative regulation of bone trabecula formation
GO:1900158	negative regulation of bone mineralization involved in bone maturation
GO:2000273	positive regulation of receptor activity
GO:2000727	positive regulation of cardiac muscle cell differentiation

Cellular Component

GO:0005615	extracellular space
GO:0009986	cell surface

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000166923

View Gene Order

ENSBTAG00000046604

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

bmppathway

BMP receptor signaling

Cross-References

SwissProt

O70326

TrEMBL

Q3TNY7 Q3UY25

UniProt Splice Variant

Entrez Gene

23892

UniGene

RefSeq

NM_011824 XM_006499444

OMIM

CCDS

CCDS16560

HPRD

IMGT

MGI ID

MGI:1344337

MGI Symbol

Grem1

EMBL

AF045801 AF108189 AK135022 AK157793 AK164871 BC015293 CH466519

GenPept

AAC40111 AAD54056 AAH15293 BAE22388 BAE34201 BAE37950 EDL27855

RNA Seq Atlas

23892