Version 5.4
Mus musculus Gene: Cs
Summary
InnateDB Gene IDBG-197262.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cs
Gene Name citrate synthase
Synonyms 2610511A05Rik; 9030605P22Rik; ahl4; BB234005; Cis
Species Mus musculus
Ensembl Gene ENSMUSG00000005683
Encoded Proteins
IDBP-197264
citrate synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000062485:
The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:128337832-128362479
Strand Forward strand
Band D3
Transcripts
ENSMUST00000005826 ENSMUSP00000005826
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004108 citrate (Si)-synthase activity
GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0044262 cellular carbohydrate metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000062485
View Gene Order
ENSBTAG00000004371
Not yet available
Pathways
NETPATH
REACTOME
REACT_189162
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_188937
Metabolism pathway
REACT_241308
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_249033
Citric acid cycle (TCA cycle) pathway
KEGG
mmu00020
Citrate cycle (TCA cycle) pathway
mmu00630
Glyoxylate and dicarboxylate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118595
Mitochondrial protein import pathway
REACT_1785
Citric acid cycle (TCA cycle) pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_17015
Metabolism of proteins pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
REACT_215469
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_219139
Metabolism pathway
REACT_220485
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_227707
Citric acid cycle (TCA cycle) pathway
KEGG
hsa00020
Citrate cycle (TCA cycle) pathway
hsa00630
Glyoxylate and dicarboxylate metabolism pathway
INOH
INOH website
Citrate cycle pathway
PID NCI
Cross-References
SwissProt Q9CZU6
TrEMBL Q0QEL9
UniProt Splice Variant
Entrez Gene 12974
UniGene Mm.413891
RefSeq NM_026444
OMIM
CCDS CCDS24273
HPRD
IMGT
MGI ID MGI:88529
MGI Symbol Cs
EMBL AB056479 AK012151 AK145643 AK149990 AK163273 AK166814 AK167125 BC013554 BC029754 DQ403125
GenPept AAH13554 AAH29754 ABD77258 BAB28063 BAB63945 BAE26560 BAE29218 BAE37268 BAE39041 BAE39273
RNA Seq Atlas 12974

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca