InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cnr2

Summary

InnateDB Gene

IDBG-197357.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cnr2

Gene Name

cannabinoid receptor 2 (macrophage)

Synonyms

CB-2; CB2; CB2-R

Species

Mus musculus

Ensembl Gene

ENSMUSG00000062585

Encoded Proteins

IDBP-197359

cannabinoid receptor 2 (macrophage)

IDBP-197361

cannabinoid receptor 2 (macrophage)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188822:
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:135895394-135920207

Strand

Forward strand

Band

Transcripts

ENSMUST00000097843	ENSMUSP00000095454
ENSMUST00000068830	ENSMUSP00000069957

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004949	cannabinoid receptor activity

Biological Process

GO:0001975	response to amphetamine
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0019233	sensory perception of pain
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0032496	response to lipopolysaccharide
GO:0033004	negative regulation of mast cell activation
GO:0038171	cannabinoid signaling pathway
GO:0045759	negative regulation of action potential
GO:0050728	negative regulation of inflammatory response
GO:0051001	negative regulation of nitric-oxide synthase activity

Cellular Component

GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043204	perikaryon