InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mapkapk5

Summary

InnateDB Gene

IDBG-197365.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mapkapk5

Gene Name

MAP kinase-activated protein kinase 5

Synonyms

MK5; PRAK

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029454

Encoded Proteins

IDBP-197367

MAP kinase-activated protein kinase 5

IDBP-257387

MAP kinase-activated protein kinase 5

IDBP-257389

MAP kinase-activated protein kinase 5

IDBP-257391

MAP kinase-activated protein kinase 5

IDBP-257393

MAP kinase-activated protein kinase 5

IDBP-534315

MAP kinase-activated protein kinase 5

IDBP-540752

MAP kinase-activated protein kinase 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089022:
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:121518613-121545905

Strand

Reverse strand

Band

Transcripts

ENSMUST00000031410	ENSMUSP00000031410
ENSMUST00000111786	ENSMUSP00000107416
ENSMUST00000111783	ENSMUSP00000107413
ENSMUST00000111782	ENSMUSP00000107412
ENSMUST00000111781	ENSMUSP00000107411
ENSMUST00000125946
ENSMUST00000126524
ENSMUST00000152270	ENSMUSP00000116464
ENSMUST00000128782
ENSMUST00000153763	ENSMUSP00000119182
ENSMUST00000154628
ENSMUST00000151352
ENSMUST00000131914

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0051019	mitogen-activated protein kinase binding

Biological Process

GO:0006417	regulation of translation
GO:0006468	protein phosphorylation
GO:0007265	Ras protein signal transduction
GO:0009103	lipopolysaccharide biosynthetic process
GO:0032007	negative regulation of TOR signaling
GO:0046777	protein autophosphorylation
GO:0090400	stress-induced premature senescence