Version 5.4
Mus musculus Gene: Rassf1
Summary
InnateDB Gene IDBG-197637.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rassf1
Gene Name Ras association (RalGDS/AF-6) domain family member 1
Synonyms 123F2; AA536941; AU044980; NORE2A; Rassf1A; Rassf1B; Rassf1C; RDA32; REH3P21
Species Mus musculus
Ensembl Gene ENSMUSG00000010067
Encoded Proteins
IDBP-197639
Ras association (RalGDS/AF-6) domain family member 1
IDBP-197641
Ras association (RalGDS/AF-6) domain family member 1
IDBP-400371
Ras association (RalGDS/AF-6) domain family member 1
IDBP-400372
Ras association (RalGDS/AF-6) domain family member 1
IDBP-535320
Ras association (RalGDS/AF-6) domain family member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000068028:
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:107551555-107562263
Strand Forward strand
Band F1
Transcripts
ENSMUST00000093786 ENSMUSP00000091301
ENSMUST00000010211 ENSMUSP00000010211
ENSMUST00000122225 ENSMUSP00000113252
ENSMUST00000121635 ENSMUSP00000113037
ENSMUST00000125080
ENSMUST00000156198 ENSMUSP00000117722
ENSMUST00000144129
ENSMUST00000125386
ENSMUST00000129320
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0006974 cellular response to DNA damage stimulus
GO:0007050 cell cycle arrest
GO:0007165 signal transduction
GO:0007265 Ras protein signal transduction
GO:0031398 positive regulation of protein ubiquitination
GO:0035556 intracellular signal transduction
GO:0050821 protein stabilization
GO:0071157 negative regulation of cell cycle arrest
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000068028
View Gene Order
ENSBTAG00000020963
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05219
Bladder cancer pathway
mmu05223
Non-small cell lung cancer pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05223
Non-small cell lung cancer pathway
hsa05219
Bladder cancer pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
p53regulationpathway
p53 pathway
Cross-References
SwissProt Q99MK9
TrEMBL A9YZW8
UniProt Splice Variant
Entrez Gene 56289
UniGene Mm.12091 Mm.462172 Mm.488708
RefSeq NM_001243748 NM_019713 XM_006511770
OMIM
CCDS CCDS57699 CCDS23494
HPRD
IMGT
MGI ID MGI:1928386
MGI Symbol Rassf1
EMBL AF132851 AF333027 BC002173 CH466560 EU314810
GenPept AAD30061 AAH02173 AAK21200 AAK21201 ABY27299 EDL21198
RNA Seq Atlas 56289

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca