InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hyal3

Summary

InnateDB Gene

IDBG-197810.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hyal3

Gene Name

hyaluronoglucosaminidase 3

Synonyms

Hyl3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036091

Encoded Proteins

IDBP-197812

hyaluronoglucosaminidase 3

IDBP-532112

hyaluronoglucosaminidase 3

IDBP-531580

hyaluronoglucosaminidase 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186792:
This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:107580818-107587359

Strand

Forward strand

Band

Transcripts

ENSMUST00000040059	ENSMUSP00000042667
ENSMUST00000148440	ENSMUSP00000119499
ENSMUST00000149487	ENSMUSP00000117845

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004415	hyalurononglucosaminidase activity
GO:0033906	hyaluronoglucuronidase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006954	inflammatory response
GO:0009615	response to virus
GO:0030214	hyaluronan catabolic process
GO:0046677	response to antibiotic
GO:0051216	cartilage development
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071493	cellular response to UV-B