Version 5.4
Mus musculus Gene: Me3
Summary
InnateDB Gene IDBG-198387.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Me3
Gene Name malic enzyme 3, NADP(+)-dependent, mitochondrial
Synonyms 1700020C08Rik; B230207H15Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000030621
Encoded Proteins
IDBP-198389
malic enzyme 3, NADP(+)-dependent, mitochondrial
IDBP-198391
malic enzyme 3, NADP(+)-dependent, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151376:
Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:89632392-89854359
Strand Forward strand
Band D3
Transcripts
ENSMUST00000032853 ENSMUSP00000032853
ENSMUST00000032856 ENSMUSP00000032856
ENSMUST00000159504
ENSMUST00000162145
ENSMUST00000159167
ENSMUST00000159491
ENSMUST00000160995
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004470 malic enzyme activity
GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity
GO:0004473 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
GO:0008948 oxaloacetate decarboxylase activity
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006090 pyruvate metabolic process
GO:0006108 malate metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000151376
View Gene Order
ENSBTAG00000000246
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00620
Pyruvate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00620
Pyruvate metabolism pathway
INOH
INOH website
Glycolysis Gluconeogenesis pathway
INOH website
Pyruvate metabolism pathway
PID NCI
Cross-References
SwissProt Q8BMF3
TrEMBL E9PZP7 Q3UZW5
UniProt Splice Variant
Entrez Gene 109264
UniGene Mm.334011 Mm.400319 Mm.468065
RefSeq NM_181407 XM_006507189 XM_006507190 XM_006507194
OMIM
CCDS CCDS21443
HPRD
IMGT
MGI ID MGI:1916679
MGI Symbol Me3
EMBL AC164643 AC165077 AK032196 AK133593 BC099935
GenPept AAH99935 BAC27751 BAE21740
RNA Seq Atlas 109264

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca