Version 5.4
Mus musculus Gene: Traip
Summary
InnateDB Gene IDBG-198670.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Traip
Gene Name TRAF-interacting protein
Synonyms Trip
Species Mus musculus
Ensembl Gene ENSMUSG00000032586
Encoded Proteins
IDBP-198674
TRAF-interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19151749
[Homo sapiens] TRAIP is a SYK antagonist in TNF signaling - overexpression of TRAIP sensitize cells to TNF-induced apoptosis.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183763:
This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:107950963-107972268
Strand Forward strand
Band F1
Transcripts
ENSMUST00000049348 ENSMUSP00000040001
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0007165 signal transduction
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005730 nucleolus
GO:0005886 plasma membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000183763
View Gene Order
ENSBTAG00000004877
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8VIG6
TrEMBL
UniProt Splice Variant
Entrez Gene 22036
UniGene
RefSeq NM_011634 XM_006511693
OMIM
CCDS CCDS23511
HPRD
IMGT
MGI ID MGI:1096377
MGI Symbol Traip
EMBL AK012786 AK012948 BC006929 BC017374 U77844
GenPept AAB52994 AAH06929 AAH17374 BAB28469 BAB28567
RNA Seq Atlas 22036

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca