InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pthlh

Summary

InnateDB Gene

IDBG-198804.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pthlh

Gene Name

parathyroid hormone-like peptide

Synonyms

PTH-like; Pthrp

Species

Mus musculus

Ensembl Gene

ENSMUSG00000048776

Encoded Proteins

IDBP-198806

parathyroid hormone-like peptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000087494:
The protein encoded by this gene is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. [provided by RefSeq, Nov 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:147252101-147264167

Strand

Reverse strand

Band

Transcripts

ENSMUST00000052296

ENSMUSP00000051433

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0051428	peptide hormone receptor binding

Biological Process

GO:0001501	skeletal system development
GO:0001958	endochondral ossification
GO:0002076	osteoblast development
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007492	endoderm development
GO:0008284	positive regulation of cell proliferation
GO:0010468	regulation of gene expression
GO:0016485	protein processing
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0030855	epithelial cell differentiation
GO:0032331	negative regulation of chondrocyte differentiation
GO:0043129	surfactant homeostasis
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0048286	lung alveolus development
GO:0060649	mammary gland bud elongation
GO:0060659	nipple sheath formation