Version 5.4
Mus musculus Gene: Rap1gap
Summary
InnateDB Gene IDBG-198973.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rap1gap
Gene Name Rap1 GTPase-activating protein
Synonyms 1300019I11Rik; 2310004O14Rik; AI427470; ARPP-90; Rap1ga1; Rap1GAP1
Species Mus musculus
Ensembl Gene ENSMUSG00000041351
Encoded Proteins
IDBP-198977
Rap1 GTPase-activating protein
IDBP-198979
Rap1 GTPase-activating protein
IDBP-270026
Rap1 GTPase-activating protein
IDBP-533840
Rap1 GTPase-activating protein
IDBP-540754
Rap1 GTPase-activating protein
IDBP-532380
Rap1 GTPase-activating protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000076864:
This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:137664726-137729861
Strand Forward strand
Band D3
Transcripts
ENSMUST00000047243 ENSMUSP00000042473
ENSMUST00000097837 ENSMUSP00000095448
ENSMUST00000105835 ENSMUSP00000101461
ENSMUST00000139831
ENSMUST00000156683
ENSMUST00000152567 ENSMUSP00000115391
ENSMUST00000150928 ENSMUSP00000123561
ENSMUST00000131536
ENSMUST00000141306 ENSMUSP00000122315
ENSMUST00000148054
ENSMUST00000151601
ENSMUST00000123011
ENSMUST00000123134
ENSMUST00000144059
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0017016 Ras GTPase binding
GO:0030695 GTPase regulator activity
GO:0042803 protein homodimerization activity
GO:0046582 Rap GTPase activator activity
Biological Process
GO:0032318 regulation of Ras GTPase activity
GO:0032854 positive regulation of Rap GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0050790 regulation of catalytic activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0000139 Golgi membrane
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000076864
View Gene Order
ENSBTAG00000008952
Not yet available
Pathways
NETPATH
REACTOME
REACT_230745
Immune System pathway
REACT_237855
Rap1 signalling pathway
REACT_229531
Adaptive Immune System pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_23
TSH pathway
REACTOME
REACT_23898
Rap1 signalling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt A2ALS5
TrEMBL
UniProt Splice Variant
Entrez Gene 110351
UniGene Mm.438991
RefSeq NM_029563 XM_006538481 NM_001081155 NM_001256218
OMIM
CCDS CCDS38925 CCDS57306
HPRD
IMGT
MGI ID MGI:109338
MGI Symbol Rap1gap
EMBL AK172955 AL805954 BC030891 BC052065
GenPept AAH30891 AAH52065 BAD32233
RNA Seq Atlas 110351

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca