Version 5.4
| Mus musculus Gene: Orai1 | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Gene | IDBG-199057.6 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | Orai1 | ||||||||||||
| Gene Name | ORAI calcium release-activated calcium modulator 1 | ||||||||||||
| Synonyms | D730049H07Rik; orai-1; Tmem142a | ||||||||||||
| Species | Mus musculus | ||||||||||||
| Ensembl Gene | ENSMUSG00000049686 | ||||||||||||
| Encoded Proteins |
ORAI calcium release-activated calcium modulator 1
ORAI calcium release-activated calcium modulator 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
| InnateDB Annotation | |||||||||||||
| Summary |
Orai1 supports the influx of extracellular Ca(2+), which is required for production of reactive oxygen species in phagocytosis.
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| InnateDB Annotation from Orthologs | |||||||||||||
| Summary |
[Homo sapiens] ORAI1 supports the influx of extracellular Ca(2+), which is required for production of reactive oxygen species in phagocytosis.
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| Entrez Gene | |||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011] |
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| Gene Information | |||||||||||||
| Type | Protein coding | ||||||||||||
| Genomic Location | Chromosome 5:123015074-123030450 | ||||||||||||
| Strand | Forward strand | ||||||||||||
| Band | F | ||||||||||||
| Transcripts |
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| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME |
Signaling by the B Cell Receptor (BCR) pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
Platelet homeostasis pathway
Hemostasis pathway
Platelet calcium homeostasis pathway
Immune System pathway
Adaptive Immune System pathway
Elevation of cytosolic Ca2+ levels pathway
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| KEGG |
Calcium signaling pathway pathway
Primary immunodeficiency pathway
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| INOH | |||||||||||||
| PID NCI | |||||||||||||
| Cross-References | |||||||||||||
| SwissProt | Q8BWG9 | ||||||||||||
| TrEMBL | A3KCG1 | ||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 109305 | ||||||||||||
| UniGene | Mm.218582 | ||||||||||||
| RefSeq | NM_175423 XM_006530117 | ||||||||||||
| OMIM | |||||||||||||
| CCDS | CCDS39261 | ||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| MGI ID | MGI:1925542 | ||||||||||||
| MGI Symbol | Orai1 | ||||||||||||
| EMBL | AB271214 AK052573 AK085755 AM712355 BC023149 | ||||||||||||
| GenPept | AAH23149 BAC35045 BAC39533 BAF47905 CAN36426 | ||||||||||||
| RNA Seq Atlas | 109305 | ||||||||||||