InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mc1r

Summary

InnateDB Gene

IDBG-199166.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mc1r

Gene Name

melanocortin 1 receptor

Synonyms

e; Mshra; Tob

Species

Mus musculus

Ensembl Gene

ENSMUSG00000074037

Encoded Proteins

IDBP-199168

melanocortin 1 receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000258839:
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:123407082-123410742

Strand

Forward strand

Band

Transcripts

ENSMUST00000098324

ENSMUSP00000095929

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004977	melanocortin receptor activity
GO:0004980	melanocyte-stimulating hormone receptor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0042562	hormone binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0010739	positive regulation of protein kinase A signaling
GO:0019233	sensory perception of pain
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0032720	negative regulation of tumor necrosis factor production
GO:0035556	intracellular signal transduction
GO:0042438	melanin biosynthetic process
GO:0043473	pigmentation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051897	positive regulation of protein kinase B signaling
GO:0060259	regulation of feeding behavior
GO:0070914	UV-damage excision repair
GO:0090037	positive regulation of protein kinase C signaling
GO:2000253	positive regulation of feeding behavior